Treatment centre size, entry to trials, and survival in acute lymphoblastic leukaemia.

Down's syndrome and acute lymphoblastic leukaemia: clinical features and response to treatment.

AIMS To examine the clinical and biological features of acute lymphoblastic leukaemia in children with Down's syndrome (DS), to compare their survival with other children, and to determine if entry to trials and survival has improved. METHODS Examination of presenting features and response to treatment in patients treated in two consecutive national trials, MRC UKALL X and XI. RESULTS The p...

Investigation of TEL/AML1 and BCR/ABL Fusion Genes in Patients Affected by Acute Lymphoblastic Leukaemia Using Interphase in situ Hybridization

Long-term results of national treatment trials in childhood acute lymphoblastic leukaemia in several Middle/East European countries

Acute lymphoblastic leukaemia (ALL) is the most frequent childhood cancer. During the last 50 years its prognosis has improved from zero probability of survival in the 1950s to more than 80% chance to be cured at the beginning of the 21st century. ALL is a highly chemosensitive disease and its successful treatment is a good indicator of the level of medical care that children with cancer get in...

Gene variants of CYP1A1 and CYP2D6 and the risk of childhood acute lymphoblastic leukaemia; outcome of a case control study from Kashmir, India

Studies on associations of various polymorphisms in xenobiotic metabolizing genes with different cancers including acute lymphoblastic leukaemia (ALL) are mixed and inconclusive. The current study analyzed the relationship between polymorphisms of phase I xenobiotic metabolizing enzymes, cytochromes P450 1A1 (CYP1A1) and CYP2D6 and childhood ALL in Kashmir, India. We recruited 200 confirmed ALL...

Determining factors contributing to the five-year survival of children suffering from acute lymphoblastic leukemia based on tree survival model in the presence of competing risks

Abstract Background and objectives: Leukemia is one of the most prevalent cancers worldwide. The relapse of the disease mitigates patient survival time. The convenience of explaining the results obtained from analyzing tree models have encouraged doctors and paramedics to employ them in their research. The current study is an attempt to determine the five-year survival time and factors influen...